Scientist in preclinical molecular imaging (M/F)
The Oncology Department of the analysis faculty GROW comprises analysis initiatives carried out inside the College of Well being, Medication and Lifestyles Sciences, the College Health center of Maastricht and the MAASTRO Hospital. The objectives of this department are at the one hand to achieve insights into the elemental biology of the most cancers procedure, and at the different to broaden new healing methods in keeping with ideas evolved within the laboratory. The rational construction of latest therapies, subsequently, comes to the shut collaboration between elementary scientists and scientific researchers. 3 primary analysis strains may also be prominent inside the Oncology Department through which a number of analysis teams are operating.
MAASTRO Lab , embedded inside the GROW analysis institute of the College of Well being, Medication and Lifestyles Sciences at Maastricht College, is a elementary and translational analysis laboratory. Analysis performed previously has been targeted at the tumour microenvironment and EGFR signalling pathways of relevance to radiation oncology. MAASTRO Lab has made a number of necessary discoveries in those fields, together with demonstration that EGFR is up regulated through radiation and that hypoxia inhibits the initiation step of mRNA translation. As well as, we have now initiated translational and scientific research in keeping with those effects together with each section I novel remedy and molecular imaging trials in addition to a Biobank venture with extra then 1500 sufferers incorporated.
The lab has 4 everlasting scientists, 5 technicians, extra then 5 PhD scholars and is totally provided for mobile tradition, molecular biology, drift cytometry, hypoxia, gene expression, proteomics and microscopy. Get right of entry to to experience, apparatus and sources inside the a lot greater GROW analysis institute and different amenities within the College also are readily to be had, together with the genome centre, complex microscopy, and the animal facility with its imaging facility (Optical imager, MRI 7 Tesla and micro CTPET to come back). MAASTRO has a structural collaboration with the VU in Amsterdam on molecular PET biomarkers, with the TU/Eindhoven on Methods Biology and is beginning a brand new collaboration with the College of Toronto on analysis associated with the Spread out Protein Reaction and tumour hypoxia.
GROW has a emptiness for a two years postdoc place
Scientist in preclinical molecular imaging focussed on analysis associated with tumour acidosis and tumour hypoxia (M/F)
On this place you’ll be accountable for wearing out preclinical and translational analysis focussed on analysis associated with (pre)scientific molecular imaging focussed on analysis associated with tumour acidosis and tumour hypoxia. You’ll pursue the analysis program on molecular imaging in conjunction with Prof. Lambin, the chief of the venture crew and may have get right of entry to to leading edge fluorescent, SPECT, PET biomarkers associated with tumour hypoxia and tumour acidosis. In case you are prepared to take action you’ll be concerned with scientific trials of latest PET biomarkers. A hit grant packages to prestigious (inter)nationwide organizations (similar to VENI or VIDI from ZonMW) to enhance, after the primary two years (already funded), your analysis actions will represent the most important a part of your paintings.
We’re on the lookout for a junior scientist with a PhD and revel in in preclinical molecular imaging (primary criterion), elementary molecular biology or mobile biology or symbol processing. Applicants will have to have a confirmed monitor report or reveal a robust possible to serve as as a essential investigator, with peer-reviewed medical publications (minimal 8 with imply have an effect on issue upper then 3.5). Applicants will have to have revel in and data of preclinical molecular imaging (extra in particular PET and/or MRI-MRS and/or optical imaging) and, if imaginable, have an experience inside the explicit analysis house of hypoxia and tumour acidosis. They will have to have a PhD. Talent to talk Dutch, authorization to paintings with animals and with radioactivity within the Netherlands (artwork 9 certificates and “stralingshygiëne Niv 5b” respectively) is a prerequisite. We’re on the lookout for a undoubtedly minded scientist inspire to be informed new approaches and in a position to spend a while in another country for complementary coaching. Revel in in collaboration with clinicians and with Eu networks is a plus however isn’t a prerequisite.
Prerequisites of Employment and wage are in keeping with the Collective Labour Settlement for Dutch Universities (CAO-Nederlandse universiteiten). You’ll obtain a two years contract methandienone legal aspects worldwide on a fulltime foundation (37 hours/week). Your wage can be in step with the size of serve as crew 10 or 11, minimal € 2916,- and most € 4284,- gross monthly on a fulltime foundation, relying in your related revel in.
Analysis Technician (M/F)
Place to be had for a analysis technician
A 2 yr place is to be had for a analysis technician (O&O medewerker 4) in wage scale 7.
Activity description
The goals of the analysis venture are to spot the healing efficiency to focus on molecular mechanisms of oxygen sensing and alterations. Hypoxic (low oxygen) spaces in human tumors are neatly documented, and lead to poorer affected person analysis. Hypoxic cells are immune to radio- and chemotherapy, and motive greater tumor development and metastasis. To be able to know the way hypoxia impacts mobile conduct, it is very important outline the molecular mechanisms that keep watch over the cell reaction to low oxygen availability. Stepped forward figuring out of those molecular pathways can give novel molecular objectives for most cancers treatment.
The technician will examine the molecular pathways that keep watch over mRNA translation all over hypoxia and can assess the healing possible of focused on those pathways. This can be completed through the usage of genetic fashions (knock-outs, dominant negatives) and through manipulating the expression ranges (overexpression, RNA interference) of key proteins that keep watch over mRNA translation. Translation potency can be monitored through polysome research, i.e. the separation of mRNA on foundation of ribosome attachment. Following polysome fractionation and RNA isolation, transcriptional and translational task of explicit genes can be assessed through microarray research and real-time. The significance of the molecular pathways for the viability of hypoxic cells can be assessed in clonogenic survival assays in addition to measurements of apoptosis. Moreover overview of healing possible can be assessed in vivo.
Necessities
We’re looking for a extremely motivated and unbiased coworker with pursuits in molecular biology and translational analysis. The candidate will have to have finished a Bachelor of Science stage as a laboratory technician and be prepared to have interaction with coworkers in English. Wisdom of elementary ways similar to in vitro mobile tradition, RT-PCR, cloning and transfection is needed. Wisdom of specialised ways similar to polysome fractionation, preparation of RNA for microarray research, clonogenic survival assays and immunohistochemistry is a bonus. Permission to paintings with animals (eg. Artwork 12) is very most popular.
We will be able to be offering an enthousiastic operating atmosphere in an bold world analysis group, see additionally our web site: http://www.maastro.com. Chances to begin a PhD-program as discussable.
Senior scientist, Head of Laboratory Analysis in Molecular Oncology (M/F)
MAASTRO, Maastricht Radiation Oncology, is a co-operation between MAASTRO health center, the College of Maastricht (UM) and the College Health center Maastricht (azM). As well as, analysis and coaching at Maastro is performed in Maastro Physics, Maastro Trials, Maastro Faculty, and Maastro Lab.
MAASTRO Lab is a elementary and translational analysis laboratory embedded inside the GROW analysis institute of the College of Well being, Medication and Lifestyles Sciences at Maastricht College.
MAASTRO lab has a emptiness for a
Senior scientist, Head of Laboratory Analysis in molecular oncology (M/F)
On this place you’ll be accountable for wearing out elementary and translational analysis this is of relevance to radiation oncology within the broadest imaginable scope. You’ll start up an unbiased analysis program in keeping with demonstrated abilities and experience in elementary sides of biology. As well as, you’ll be mainly accountable for the medical analysis and coaching inside the lab of experimental Radiation Oncology (MAASTRO lab). As head of study you’ll set up the laboratory medical analysis, direct the analysis coverage, and take part actively in ongoing and newly initiated analysis strains and initiatives. A hit grant packages to prestigious (inter)nationwide organizations to enhance enlargement of study actions will represent the most important a part of your paintings.
Relying on revel in, the method to nominate you as professor or affiliate professor on the college of Well being, Medication and Lifestyles Sciences from Maastricht College can be began. You’ll take part in analysis and academic actions inside the college. The emphasis on this college appointment is on microenvironment of forged tumours and mobile signalling (EGFR) however there may be room to your explicit house of experience.
We’re on the lookout for a senior scientist with coaching and revel in in elementary molecular biology, biochemistry, mobile biology or similar house. Applicants will have to have a confirmed monitor report or reveal a robust possible to serve as as a essential investigator, with prime have an effect on medical publications and several other huge running medical grants. Applicants will have to have revel in and data of molecular oncology and feature a known experience inside a selected analysis house related to radiation oncology. Revel in in radiation biology, collaboration with clinicians and talent to talk Dutch is a plus however is now not a prerequisite. Ideally applicants may have revel in in analysis crew control. As well as, applicants will have to be capable to formulating strategic objectives for his or her analysis program in keeping with the organisational technique.
Prerequisites of Employment and wage are in keeping with the Dutch Collective Labour Settlement for Hospitals (CAO-Ziekenhuizen). You’ll obtain an enduring contract on a fulltime foundation (36 hours/week) or a 5 years contract, relying in your related revel in.